Metabolic Regulation of Regulatory T Cell Development and Function

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Metabolic Regulation of Regulatory T Cell Development and Function

It is now well established that the effector T cell (Teff) response is regulated by a series of metabolic switches. Quiescent T cells predominantly require adenosine triphosphate-generating processes, whereas proliferating Teff require high metabolic flux through growth-promoting pathways, such as glycolysis. Pathways that control metabolism and immune cell function are intimately linked, and c...

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ژورنال

عنوان ژورنال: Frontiers in Immunology

سال: 2014

ISSN: 1664-3224

DOI: 10.3389/fimmu.2014.00590